We are pleased to share our new publication in Biophysical Journal, entitled: “Mapping the peptide interaction fingerprint of the Behçet’s disease-associated HLA-B*51.”

Our study uses all-atom molecular dynamics simulations to examine how HLA-B*51:01 interacts with 36 self-peptides. The simulations reveal interaction patterns that depend on peptide length, while in silico unbinding simulations distinguish their resistance to mechanical separation. These findings provide a molecular framework for understanding peptide recognition by this protein, the strongest genetic risk factor for Behçet’s disease.

Citation
Yilmaz, S. Z., Basturk, D., Gul, A., Erman, B., Gur, M. (2026). Mapping the peptide interaction fingerprint of the Behçet’s disease-associated HLA-B∗51. Biophysical Journal, 125(16), 4437-4449. (IF: 3.7; 5-year IF: 3.5)

View the publication
https://doi.org/10.1016/j.bpj.2026.04.028