We are pleased to share our new publication in Journal of Cell Biology, entitled: “A force-sensitive mutation reveals a non-canonical role for dynein in anaphase progression.” In this collaborative study, a series of Drosophila dynein heavy chain missense mutations were generated—including some linked to human neurological disease—to dissect how dynein’s mechanical properties shape its functions.…

We are pleased to announce the publication of our new review article, Introduction to Artificial Intelligence (AI) and Machine Learning (ML) in Pathology & Medicine: Generative & Non-Generative AI Basics, by Rashidi et al. This comprehensive paper, serving as the first in a seven-part series, covers essential AI-ML concepts, including both generative and non-generative approaches, to guide…

The Gur Lab’s Principal Investigator, Mert Gur, and member, Fareeda Elinam Abu Juam, attended ABRCMS 2024, where they promoted three programs: the TecBio program (co-directed by our PI), the Computational Biomedicine and Biotechnology program (led by our PI as Executive Director), and the joint Carnegie Mellon–University of Pittsburgh PhD Program in Computational Biology (where our…

We are excited to share our latest research published in Science Advances, titled “Influence of point mutations on PR65 conformational adaptability: Insights from molecular simulations and nanoaperture optical tweezers.” This study investigates how point mutations in the PR65 scaffold subunit of PP2A affect its conformational dynamics, leveraging in silico saturation mutagenesis, molecular dynamics simulations, and…

We are happy to announce the publication of our latest review article in AsiaChem, titled “Elastic Network Models in Protein Dynamics: Bridging Simplicity and Complexity”, authored by Gur, M., Golcuk, M., and Bahar, I. This work explores the profound role of Elastic Network Models (ENMs) in understanding protein dynamics, emphasizing their mathematical rigor and computational…

We are pleased to announce our new publication in PNAS, titled “Global hinge sites of proteins as target sites for drug binding”, by Zhang, H., Gur, M., and Bahar, I. This study demonstrates that “global hinges”—key mechanosensitive residues orchestrating large-scale protein motions—are frequently targeted by existing drugs. Harnessing these sites as novel drug-binding hotspots could…

Following the lab’s transition from İstanbul to Pittsburgh, we needed a new website to better reflect our evolving mission and objectives, showcase our innovative research projects, and promote our collaboration with local institutions and communities, ensuring that our work is accessible and engaging to a wider audience. We hope you enjoy!

Our paper titled “The mechanism and energetics of the dynein priming stroke” by Mert Golcuk, Sema Zeynep Yilmaz, Ahmet Yildiz, and Mert Gur has been published in Structure. View the publication here: https://www.cell.com/structure/fulltext/S0969-2126(24)00042-X

We are pleased to announce that Assoc. Prof. Dr. Mert Gür has joined the editorial board of the Computational and Structural Biotechnology Journal as an Associate Editor. With a CiteScore of 7.8 according to Scopus and an Impact Factor of 6 according to Clarivate, the journal continues to strive for excellence in the field. You…